miRCURY LNA miRNA Mimics
For studies on miRNA function and gene regulation using synthetic miRNA
Third generation of highly potent, mature miRNA mimics with unique triple RNA strand design
No miRNA-star activity from bisected LNA-enhanced passenger strand
miRNA strand sequence matches miRBase annotation
Available with fluorescent label to assess transfection efficiency
Available with biotinylated miRNA strand to isolate targets by RNA pull-down
miRCURY LNA miRNA Mimics are designed to simulate naturally occurring mature miRNAs. Introducing an miRNA mimic into cells increases the proportion of RNA-induced silencing complexes (RISC) containing the guide strand miRNA, enabling assessment of the phenotypic consequences of increased activity and discovery of new miRNA functions. miRCURY LNA miRNA Mimics have an innovative design that includes two short, LNA-enhanced complimentary strands that prevent any miRNA-like activity associated with the passenger strands, so you can be sure that phenotypes observed using these mimics are due to increased activity of the mimicked miRNA.
miRCURY LNA miRNA Inhibitors and Power Inhibitors
For miRNA loss-of-function studies using LNA-enhanced antisense miRNA inhibitors
•Tm-normalized inhibitors with unmatched potency against any miRNA, regardless of GC content
•Power Inhibitors so potent that they work by unassisted uptake with no need for transfection reagents
•Superior specificity and biological stability for long-lasting antisense activity
• Available in 1 nmol, 5 nmol and 15 nmol quantities
• Fluorescent labels for convenient monitoring of transfection efficiency
miRCURY LNA miRNA Inhibitors and Power Inhibitors are exceptionally potent, enabling assessment of cellular phenotypes in miRNA loss-of-function studies, even in difficult-to-transfect cell lines. miRCURY LNA miRNA Inhibitor Controls and Power Inhibitor Controls are similar in sequence length and LNA design to the inhibitors and have no homology to any known mouse, rat or human miRNA or mRNA sequence.